美沙拉嗪与柳氮磺胺吡啶治疗溃疡性结肠炎的疗效比较

Comparison of mesalazine and sulfasalazine in the treatment of ulcerative colitis

目的:探讨美沙拉嗪与柳氮磺胺吡啶治疗溃疡性结肠炎(UC)的疗效。方法:90例UC患者随机对照组45例,用柳氮磺胺吡啶治疗,观察组45例用美沙拉嗪,疗程为8周,比较两组的临床疗效。结果:治疗后观察组腹泻、腹痛、黏液血便等症状积分低于对照组;血清超敏C反应蛋白(Hs-CRP)、肿瘤坏死因子(TNF-a)等指标低于对照组;观察组总有效率93.33%,高于对照组的68.89%,差异具统计学意义(P<0.05)。结论:美沙拉嗪治疗UC临床效果比柳氮磺胺吡啶更好。

Objective： To investigate the efficacy of mesalazine and sulfasalazine in the treatment of ulcerative colitis（ UC）. Methods： A total of 90 patients with UC were randomly assigned to 45 patients in the control group,who were treated with sulfasalazine. In the observation group,45 cases were treated with mesalazine. The course of treatment was 8 weeks,and the clinical efficacy of the two groups was compared.Results： After treatment,the scores of symptoms such as diarrhea,abdominal pain and mucus blood stool in the observation group were lower than those in the control group,and the serum hypersensitivity C reactive protein（ Hs-CRP） and tumor necrosis factor（ TNF-a） were lower than the control group,and the total effective rate of the observation group was 93.33%,higher than that of the control group（ 68.89%）,and the differences were statistically significant（ P 〈 0. 05）. Conclusion： Mesalazine is better than sulfasalazine in the treatment of UC.