脊髓亚急性联合变性的临床诊疗进展

Progressinclinical diagnosis and treatment of spinalsubacute combined degeneration

脊髓亚急性联合变性(SCD)是一种神经系统变性疾病,其主要病因为维生素B_(12)的缺乏,脊髓后索、侧索和周围神经为主要受损部位。由于很多患者早期临床表现不典型以及多样性的特点导致早期诊断比较困难。脊髓亚急性联合变性诊断一旦明确,其治疗简单,治疗效果良好。若不能及时诊断与治疗,容易导致不可逆转的神经功能损害,甚至危及生命。笔者从该病的病因、发病机制、临床表现、诊断及治疗等方面进行综述。

Subacute combined degeneration（ SCD） of spinal cord is a degeneration disease of nervous system. Its main disease is vitamin B12 deficiency. Spinal cord,lateral cord and peripheral nerve are the main damaged parts. Early diagnosis is difficult,because of atypical early clinical manifestations of many patients and the characteristics of diversity. Once the diagnosis of subacute spinal cord degeneration is clear,the treatment is simple and the therapeutic effect is good. If you can’t diagnose and treat it in time,it can lead to irreversible damage of nerve function and even life. This article reviews the etiology,pathogenesis,clinical manifestation,diagnosis and treatment of the disease.