5-氰基-6-硝基吲哚的合成

Synthesis of 5-Cyano-6-nitroindole

吲哚类化合物作为医药、农药、染料以及其他精细化工产品的中间体,其应用越来越广。5-氰基-6-硝基吲哚的合成方法目前无文献报道,以5-溴吲哚为原料,经还原、硝化、保护、取代、脱保护和氧化6步反应首次合成目标产物,其结构经^1HNMR、^13CNMR和MS确证。该路线具有原料廉价易得、操作简单、后处理方便且收率较高等优点,适合工业化生产。

Indole derivatives apply more and more extensively severing as pharmaceuticals,pesticides,dyes and other fine chemical products intermediates.The synthesis of 5-cyano-6-nitroindole hasn＇t been reported in the literature up to now. This work initially synthesize it based on 5-bromoindole by means of six steps of reduction,nitration,protection,substitution,deprotection and oxidation.The structure was confirmed by ^1HNMR,^13CNMR and MS.The route can well meet with the needs of industrial production given cheap raw materials,simple operation,easy post-processing and high yield.