基于格子玻尔兹曼方法的冠状动脉血流储备分数无创计算研究

Noninvasive numerical simulation of coronary fractional flow reserve based on lattice Boltzmann method

为探讨格子玻尔兹曼方法(LBM)在基于电子计算机断层扫描(CT)的冠状动脉血流储备分数(FFRCT)无创计算中的应用,以一个局部狭窄圆管模型和两个冠状动脉分支模型为研究对象。基于开源代码库(Palabos),在集成开发环境(Codeblocks)中改进相应算法程序。基于LBM对以上模型的FFRCT进行数值模拟,并将数值模拟的结果与有限元分析软件ANSYS数值模拟的结果进行对比分析,以验证LBM数值模拟冠状动脉FFRCT的可行性。结果表明,LBM数值模拟冠状动脉FFRCT与有限元分析软件ANSYS模拟的结果相对误差在1%左右,验证了LBM数值模拟冠状动脉FFRCT可行性。本研究的模拟计算为后续开发冠状动脉FFRCT应用软件提供了技术支持,为临床冠状动脉FFRCT的计算奠定了基础。

In order to investigate the application of lattice Boltzmann method（LBM） in the numerical simulation of computed tomography angiography-derived fractional flow reserve（FFRCT）, an idealized narrowed tube model and two coronary stenosis arterymodels are studied. Based on the open source code library（Palabos）, the relative algorithm program in the development environment（Codeblocks） was improved. Through comparing and analyzing the results of FFRCT which is simulated by LBM and finite element analysis software ANSYS, and the feasibility of the numerical simulation of FFRCT by LBM was verified. The results show that the relative error between the results of LBM and finite element analysis software ANSYS is about 1%, which vertifies the feasibility of simulating the coronary FFRCT by LBM.The simulation of this study provides technical support for developing future FFRCT application software, and lays the foundation for the calculation of clinical FFRCT.