氧化应激在脊髓损伤中的研究进展

Research advances on oxidative stress in spinal cord injury

脊髓损伤（SCI）是受到直接或间接暴力损伤后导致的一种神经功能障碍的疾病，为脊柱骨折的严重并发症，按损伤机制可分为原发性损伤和继发性损伤，其中氧化应激与SCI继发性损伤的发生发展有着密切的关系。我们通过对SCI中氧化应激作用的研究，进一步阐明SCI继发性损伤的发病机制，并对近年来针对抗氧化治疗出现的抗氧化剂进行分析，为SCI的治疗提供新的方向。

Spinal cord injury （SCI） is a neurological disorder disease caused by direct or indirect violence, which is a serious complication of spinal fractures. It can be divided into primary injury and secondary injury by injury mechanism. There is a close relationship between oxidative stress and secondary injury. In this article, the pathogene- sis of secondary injury was further elucidated by the research of oxidative stress in SCI, and the anti - oxidants on anti - oxidative therapy appeared in recent years were analyzed to provide a new direction for SCI treatment.