卵圆孔未闭伴焦虑障碍与脑梗死的相关性研究

The study on the correlation between the anxiety disorder existing patent with foramen ovale and cerebral infarction

目的探讨卵圆孔未闭(PFO)伴焦虑障碍与脑梗死的相关性,为预防和治疗缺血性卒中提供新的依据。方法选取2016年1月~2017年1月在我院超声科行经颅多普勒超声(TCD)发泡实验的神经内科首次住院患者274例,进行焦虑自评量表检测。根据检测结果分为4组:第一组为焦虑障碍并PFO的患者(56例);第二组为无焦虑障碍有PFO的患者(36例);第三组为焦虑障碍无PFO的患者(48例);第四组为无焦虑障碍无PFO的患者(104例),分别记录四组患者初发型脑梗死例数及其发病情况,并进行统计学分析。结果将4组脑梗死发生率进行组间比较,除第二组与第三组脑梗死发生率差异无统计学意义(P>0.05),其余各组的组间比较差异均有统计学意义(P>0.05)。即第一组脑梗死发生率最高,第二组与第三组次之,第四组最低。结论焦虑障碍合并PFO可能会使患者发生脑梗死的机率增多,其机制可能与长期焦虑障碍使PFO患者的右向左分流增加,致脑梗死发病机率增多有关,但其确切机制还有待进一步研究。

Objective In order to provide foundation for prevention and treatment of ischemic stroke, the research for the relationship between the anxiety disorders existing patent with foramen ovale （PFO） and cerebral infarction was carried out. Methods 274 patients with PFO were divided into group one（56cases）, group two（36 cases）, group three （48 cases） and group four（104 cases）. Group one had anxiety disorder and PFO. Group two had no anxiety disorder. Groups three had anxiety disorder but no PFO. Group four had no anxiety disorder and no PFO. Results There was no significant difference of incidence of cerebral infarction between group two and group three. There was difference of incidence of cerebral infarction between he other groups. Group one had high incidence of cerebral infarction, then followed group two and group three. Group four had a relative low incidence rate. Conclusion Anxiety disorder with PFO may increase the incidence rate of cerebral infarction.