埃索美拉唑治疗老年脑卒中合并胃食管反流病患者的疗效与安全性评价

Clinical effects and safety of esomeprazole in the treatment of stroke complicating gastroesophageal reflux disease in aged people

目的探讨与评价埃索美拉唑对老年脑卒中患者合并胃食管反流病的疗效和安全性。方法纳入64例合并胃食管反流病的脑卒中老年患者,随机分为为研究组和对照组,每组各32例。研究组予以埃索美拉唑口服,1次/d,40mg/次;对照组予以奥美拉唑口服1次/d,20mg/次,均治疗8周后比较两组患者治疗前后临床疗效、内镜下评分及不良反应。结果两组患者胸痛、反酸、烧灼感等症状经治疗后均改善明显,研究组总有效率与对照组比较,差异有统计学意义(P<0.05)。两组患者的药物不良反应发生率比较差异无统计学意义(P>0.05)。结论埃索美拉唑为治疗合并胃食管反流病的脑卒中老年患者安全、有效的药物,可在临床推广应用。

Objective To examine the clinical efficacy and security of esomeprazole in therapy of stroke complicating gastroesophageal reflux disease in the aged people. Methods Sixty-four patients were randomly divided into treatment group （32 cases） and control group （32 cases）. The patients in treatment group were orally administrated with esomeprazole 40 mg once a day. The people in the matched group were administrated with Omeprazole 20mg once a day. Clinical efficacy and the drug adverse reaction were compared between the two groups after treatment for 8 weeks. Results The symptoms of chest pain,acid reflux and heartburn in two groups were improved after treatment for 8 weeks. The efficient in treatment group （84. 38%） was higher than that in control group （71. 88%）, （P〈0.05）. The incidences of adverse reaction of treatment group and control group were 9.4% and 6.3% （ P〉 0. 05）. Conclusion Esomeprazole is effective and safe in the treatment of stroke complicating gastroesophageal reflux disease in the aged people.