肺癌患者中医辨证与临床分期、组织分型及EGFR相关性研究

Research on the correlation between syndrome differentiation of traditional Chinese medicine(TCM) and the clinical stage, histological type and EGFR gene in patients with lung cancer

目的对肺癌患者的中医辨证与西医临床分期、组织分型及EGFR基因的相关性进行分析,寻找其中的规律。方法选取2015年2月~2017年9月期间入选肺癌患者101例,进行中医辨证分型与西医临床分期、组织病理分型及EGFR基因的相关性统计分析。结果肺癌中医分型与组织病理类型间差异有统计学意义(P<0.05);腺癌与小细胞肺癌及非腺癌间差异有统计学意义(P<0.05),肺癌中医辨证分型与TNM分期间有统计学意义(P<0.05);组间分析Ⅰ期与Ⅳ期、Ⅱ期与Ⅳ期间有统计学差异(P<0.05);肺癌中医辨证分型与EGFR基因表达间有统计学意义(P<0.05);肺癌患者中EGFR阳性表达依次由痰热证、气滞血瘀证、气阴两虚证、寒湿证递增,寒湿证和痰热证比较有显著差异性(P<0.05)。结论肺癌中医辨证与临床分期、组织病理分型及EGFR基因表达间有一定的相关性,可以为中医客观规范化辨证施治提供辨证依据。

Objective To analyze the relationship between syndrome differentiation of traditional Chinese medicine （TCM） and the clinical stage of western medicine, histological type and EGFR gene in patients with lung cancer and to find out the regularity among them. Methods From February 2015 to September 2017, 101 patients with lung cancer were enrolled in this study. Statistical analysis of relationship between TCM syndrome differentiation and clinical stage, histopathological type and EGFR gene expression was carried out. Results There was a significant difference （P〈0.05） between TCM types and histopathological types of lung cancer（P〈0.05）, among which, there was a significant difference （P〈0.05） between adenocarcinoma and small cell lung cancer and non-adenocarcinoma. There also had a significant difference（P〈0.05） between TCM types and TNM stage of lung cancer. Intergroup analysis demonstrated that there was a significant difference （P〈0.05） between stage Ⅰ and Ⅳ, and also stage Ⅱ and Ⅳ.There was a significant difference （P〈 0.05） between TCM types and positive expression of EGFR. From phlegm-heat syndrome, qi-stagnation syndrome, qiyin deficiency syndrome to cold-dampness syndrome, The positive expression of EGFR was gradually ascending. There was significant difference between cold-dampness syndrome and phlegm-heat syndrome（P〈0.05）. Conclusion There is a certain correlation between syndrome differentiation of TCM and clinical stage, histopathological classification and EGFR gene expression in lung cancer, which can provide dialectical evidence for objective and standardized TCM syndrome differentiation.