无创呼吸机联合复方异丙托溴铵雾化吸入在慢阻肺急性加重期中的应用

Application of non-invasive ventilator combined with compound ipratropium bromide inhalation in acute exacerbation of chronic obstructive pulmonary disease

目的无创呼吸机联合复方异丙托溴铵雾化吸入在慢阻肺急性加重期中的应用效果。方法 2013年3月~2017年3月60例慢性阻塞性肺急性加重期患者被纳入本次研究。实施随机均等分组研究,对照组实施常规治疗,如止咳化痰、抗感染等,观察组在其基础上联合实施无创呼吸机与复方异丙托溴铵雾化吸入治疗。对两组患者的住院时间、APACHEⅡ评分、两组的气管插管情况等进行比较分析。结果治疗后两组患者气管插管情况统计结果显示,对照组和观察组分别为8例和3例,气管插管率存在统计学差异(P<0.05)。另外,两组患者的氧分压以及二氧化碳分压、APACHEⅡ评分等治疗前无显著差异,治疗后差异显著,住院时间也具有统计学意义(P<0.05)。结论在对慢性阻塞性肺疾病急性加重期患者进行治疗的过程中,需要在常规治疗的基础上进行无创呼吸机联合复方异丙托溴铵雾化治疗,有效减短患者的住院时间,改善患者的氧分压等,总体治疗效果显著,具备推广使用价值。

Objective To evaluate the effect of non-invasive ventilator combined with compound ipratropium bromide inhalation in the acute exacerbation of chronic obstructive pulmonary disease. Methods 60 patients with acute exacerbation of chronic obstructive pulmonary disease were included in this study. Data were collected from March 2013 to March 2017. Participants were randomly and equally divided into observational group and control group. The control group was given routine treatment such as relieving cough and reducing sputum, anti-infection, etc. On the basis of control group, the observation group was given combined with non-invasive ventilator combined with compound ipratropium bromide inhalation therapy. The hospitalization time, APACHE Ⅱ score, tracheal intubation status of the two groups were compared and analyzed. Results The results showed that after different treatments there were 8 cases of tracheal intubation in the control group and 3 cases in the observation group, and the tracheal intubation rate was statistically different（P〈0.05）. In addition, there was no significant difference in partial pressure of oxygen, partial pressure of carbon dioxide and APACHE Ⅱ score between the two groups before treatment, while the difference was significant after treatment, and the length of hospitalization was also statistically significant（P〈0.05）. Conclusion In the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease, a non-invasive ventilator combined with compound ipratropium bromide on the basis of routine treatment can effectively shorten the hospital stay, improve the patient＇s oxygen partial pressure, and the overall treatment effect is significant, which deserve promotion.