间充质干细胞治疗慢性创面的研究进展

Advances in the research of mesenchymal stem cells in chronic wounds

创面修复一直是烧创伤领域研究的重要问题。近年来，随着社会的发展、人口老龄化的加速、生活习惯改变等原因，以大面积烧伤和糖尿病溃疡等疾病所导致的慢性难愈性创面发病率大幅增高，研究如何促进这类创面愈合成为热点，其中细胞治疗备受关注。间充质干细胞（MSC）源自中胚层，具有多能干细胞的特性，在机体分布广泛，其已知的来源包括骨髓、皮肤、胎盘、脂肪组织等。由于MSC免疫原性较弱，使其成为组织工程种子细胞的理想选择。因此，很多学者近年来一直在致力于研究使用MSC修复慢性难愈性创面，现就有关进展综述如下。

Skin is the largest organ in the body, with a variety of functions, such as thermoregulation, physical barriers, and sensory transmission, etc. Therefore, to restore the function after injury as soon as possible is particularly important. Mesenchymal stem cells （MSCs） are derived from mesoderm, and can differentiate into a variety of tissues, such as cartilaginous tissue, myoideum, and adipose tissue. Weak immunogenicity of MSCs make them become the ideal seed cells of tissue engineering. MSCs have a wide range of sources, including known sources of bone marrow, skin, placenta, and adipose tissue, etc. MSCs from different sources also have many different mechanisms in wound repair. This article reviews the recent researches on MSCs in the treatment of chronic wounds, so as to explore new ideas for the clinical treatment of chronic wounds.