摘要
目的:针对淋巴管平滑肌瘤病患者的观察并分析其病理特征。方法:选择光山县人民医院2014年8月至2017年7月收治的10例肺淋巴管平滑肌瘤病患者为研究对象,查阅相关文献并对其形态学组织进行观察、分析,对其免疫组化展开检验并分析。结果:免疫学检验中,增生的平滑肌样梭形细胞均表现为阳性;细胞核有少部分抗体阳性呈现;增生淋巴管内皮细胞以淋巴管+(D2–40)、Ⅷ因子(FⅧ)以及高度糖基化的i型跨膜糖蛋白(CD34)呈现出阳性表达。结论:肺淋巴管平滑肌瘤病发病年龄大多为育龄女性,发病原因以沿支气管淋巴管、血管淋巴管、平滑肌细胞等增生异常为主。
Objective To observe and analyze the pathological features of pulmonary lymphangioleiomyomatosis in patients with pulmonary lymphangioma. Methods Ten patients in Guangshan county people's hospital with pulmonary lymphangiomyosarcoma were selected as study subjects from August 2014 to July 2017. The related literatures were examined and their morphological tissues were observed and analyzed. Immunohistochemistry was performed and analyzed. Results In the immunological test, the proliferation of smooth muscle-like spindle cells showed negative in addition to MRAT-1, the others were positive; the nucleus was partially ER and PR positive; the lymphatic endothelial cells proliferated with D2-40, F VIII and CD34 showed positive expression. Conclusion Pulmonary lymphangiomyosarcoma is mostly aged for women of childbearing age.The pathogenesis is mainly due to dysplasia of bronchial lymphatic vessels, vascular lymphatic vessels and smooth muscle cells.
作者
张道省
宋文斌
王梦欣
ZHANG Dao-sheng;SONG Wen-bin;WANG Meng-xin(Guangshan County People's Hospital, Henan Guangshan 46545)
出处
《深圳中西医结合杂志》
2018年第6期94-96,共3页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
关键词
肺淋巴管平滑肌瘤病
免疫组化
组织形态学
Pulmonary lymphangiomyosarcoma
Immunohistochemistry
Morphological organization