天癸、BMSCs与PMOP的理论关系研究

Study on the Theoretical Relationship Between Tian Gui,BMSCs and PMOP

"天癸"是一个比较经典的中医学词汇,天癸的充盈衰竭与绝经后骨质疏松症的发病机理存在一定的理论相关性。故试通过总结中医学和现代医学"肾精""天癸"理论的内涵,初步探讨"天癸""肾精"与绝经后骨质疏松症的理论关系,指出绝经后骨质疏松症发病机制与肾精、天癸的关系较为密切。肾精亏虚、天癸衰竭是绝经后骨质疏松症发病的根本病机。结合现代医学对骨髓间充质干细胞的研究,骨髓间充质干细胞向成骨与成脂分化机制途径影响骨代谢平衡,骨髓间充质干细胞可以看作是肾精与天癸在绝经后骨质疏松症发病机制在细胞层面的微观体现。在治疗方面,初步提出补肾精益天癸的治疗方法,以期为绝经后骨质疏松症的预防与治疗提供相关的理论依据与指导。

＂Tiangui＂is a classic Chinese Medicine term. Through summarizing traditional Chinese medicine and modern medicine theory of ＂kidney essence＂ ＂Tiangui ＂ connotation,preliminary discussion ＂ Tiangui ＂ and ＂ kidney essence＂ and the theory of their relationship with postmenopausal osteoporosis. The article points out that the pathogenesis of postmenopausal osteoporosis and kidney essence,tiangui more closely. Kidney essence deficiency,tiangui failure is the fundamental pathogenesis of postmenopausal osteoporosis. Combined with modern medical study of bone marrow mesenchymal stem cells between bone marrow mesenchymal stem cells to differentiate mechanism of fat of osteogenesis and its way to affect bone metabolism balance. Bone marrow mesenchymal stem cells can be seen as a kidney essence with tiangui in the pathogenesis of postmenopausal osteoporosis in microscopic embodiment of cellular level. Put forward the treatment of tonic kidney essence and tiangui,so as to provide relevant theoretical basis and guidanc for the prevention and treatment of postmenopausal osteoporosis.