环境响应性载体材料在农药控释中的应用研究进展

Recent progress on stimuli-responsive materials as pesticides controlled release carriers

环境响应性载体材料是一种新兴的智能复合材料,能够响应酶、氧化还原、pH值、光、温度、电场、磁场和离子强度等环境刺激的变化,实现有效成分的靶向控制释放,在药物控释方面表现出突出的优越性,具有广阔的应用前景,已成为目前医药、食品和环境工程等领域的研究热点。文章综述了环境响应性载体材料的种类及其在农药领域的研究及应用状况,探讨了以环境响应性载体材料作为农药载体时存在的问题,并对其应用前景进行了展望。目前常见的环境响应性载体材料主要包括酶响应性载体材料、pH响应性载体材料、氧化还原响应性载体材料、光响应性载体材料及温度响应性载体材料等种类,已被广泛应用于药物传递、分离纯化、临床诊断以及酶和细胞的固定化等领域,其作为助剂在农药制剂加工中的应用尚处于基础阶段,在商业化与规模化应用等方面还有待进一步研究完善。

The stimuli-responsive carrier material is an emerging type of composite material, which can achieve self-regulated controlled-release in response to the change of enzyme, redox, p H,photoirradiation, temperature, electric field, magnetic field and ionic strength in external environment.Materials of this type exhibit excellent advantages for drug controlled-releasing and extensive application prospect. Therefore, they have attracted worldwide interest in the field of medicine, food and environmental engineering. The research progress in the field of stimuli-responsive carrier materials and their application as carrier of pesticides were discussed. Potential problems of employing stimuliresponsive carrier materials as pesticides controlled release carriers and its prospective were also discussed. Stimuli-responsive carrier materials, including enzyme-, p H-, redox-, photoirradiation-and temperature-responsive carrier materials, have been widely used in the field of drug delivery,purification, diagnostics, and immobilization of enzymes and cells. The application of stimuliresponsive carrier materials in pesticide formulation process is still in the basic stage, and need to be further studied in the aspects of commercialization and scale application.