基于知识图谱的2型糖尿病发病机制研究的可视化分析

Visualization research on mechanism of type 2 diabetes mellitus based on mapping knowledge domain

目的:分析2型糖尿病(type 2 diabetes mellitus,T2DM)机制研究的发展历程,探测T2DM研究热点及前沿。方法:以Web of Science数据库中2008至2015年发表的5 144篇T2DM发病机制研究论文为研究对象,借助图谱可视化软件Cite SpaceⅢ,获得研究国家合作图谱、主流学术群体图谱、文献被引图谱、高频关键词的共现及词频变动趋势图谱。结果:近年来T2DM发病机制研究呈现明显的发展趋势;研究力量主要集中在美国、中国、日本、英国、德国等患病率较高的国家;研究内容主要围绕胰岛素抵抗和胰岛细胞功能失调展开,并涉及遗传易感性、肥胖、炎症、肠道菌群紊乱以及糖尿病并发症等其他高危因素。结论:在患病率较高的国家,T2DM发病机制研究得到高度重视,不同途径引起的胰岛素抵抗引发疾病的机制是目前相关领域研究的核心内容。

Objective ：To analyze the development process of pathogenesis of type 2 diabetes mellitus（T2DM） and its research hotspots and frontiers of research. Methods ：The web of science was searched for articles published during 2008-2015 and studies related to the pathogenesis of T2DM were selected. Data were analyzed by CiteSpasce Ⅲ. Results：In recent years, study on pathogenesis of T2DM shows a developing trend obviously. Core academic groups are mainly distributed in the United States,China,Japan, England, Germany and other countries with high prevalence. Focus of the study revolves around insulin resistance and islet cell function dis- order, including genetic susceptibility, obesity,inflammation, gut microbiota disruption, and diabetes complications. Conclusion ： In countries with high prevalence of T2DM, the mechanism research have been attached great importance. And in recently,the insulinresistance induced by different pathways is the core content in the fields of mechanism study.