2型糖尿病患者血清锌α2糖蛋白与血脂的相关性

Correlation between serum Zinc-α2-glycoproteins level and serum lipids in type 2 diabetes mellitus

目的:探讨2型糖尿病(type 2 diabetes mellitus,T2DM)患者血清锌α2糖蛋白(Zinc-α2-glycoproteins,ZAG)与血脂的相关性。方法:选取新诊断T2DM患者90例与正常健康者87例,记录一般临床指标;收集所有受试者的空腹血清标本,酶法测定血脂水平,ELISA法检测血清ZAG水平,Pearson相关和多元逐步回归分析ZAG与血脂的相关性。结果:与对照组相比,T2DM组血清ZAG水平降低[(59.69±12.97)vs.(36.07±12.15)mg/L,P=0.000],非超重T2DM组和超重T2DM组血清ZAG水平均降低[(60.95±13.05)vs.(38.93±10.59)mg/L,P=0.000;(56.36±12.42)vs.(33.78±12.92)mg/L,P=0.000]。相关性分析和多元逐步回归分析显示T2DM组空腹血清ZAG与HDL-C(r=0.345,P=0.001)、BMI(r=-0.330,P=0.002)、HOMA-IR(r=-0.290,P=0.006)相关。以HDL-C=1.04 mmol/L分层分析显示T2DM患者HDL-C≥1.04组较HDL-C<1.04组的血清ZAG水平升高[(38.01±12.62)vs.(30.75±9.00)mg/L,P=0.011];对照组空腹血清ZAG水平与TC呈正相关(r=0.292,P=0.006),以TC=5.18 mmol/L为切点进行分层分析发现对照组中TC≥5.18组较TC<5.18组的血清ZAG水平升高[(63.36±12.03)vs.(56.97±13.09)mg/L,P=0.022]。结论:脂肪细胞因子ZAG可能与T2DM脂代谢紊乱过程有关,并且ZAG对促进脂代谢稳态可能具有有利作用。

Objective：To investigate the relationship between serum Zinc-α2-glycoproteins （ZAG） level and serum lipids in type 2 diabetes mellitus（T2DM）. Methods：Ninety newly diagnosed T2DM patients and eighty-seven healthy people were enrolled in the study. General clinical indices were recorded and fasting serum samples were collected from all subjects, serum lipids levels were mea- sured by enzymatic methods. Serum ZAG level was measured by ELISA. The relationship between ZAG and serum lipids were ana- lyzed by Pearson correlation analysis and multiple stepwise regression analysis. Results：The level of serum ZAG in patients with T2DM was lower than that of control group[（59.69 ± 12.97） vs. （36.07± 12.15） mg/L,P=0.000],the level of fasting serum ZAG was lower in both non overweight T2DM group and overweight group[（60.95 ± 13.05） vs. （38.93 ±10.59） mg/L,P=-0.000; （56.36 ± 12.42） vs. （33.78 ± 12.92） mg/L,P=0.000]. The fasting serum ZAG level was correlated with HDL-C（r=0.345,P=0.001）,BMI（r=-0.330,P= 0.002）, HOMA-IR（r=-0.290,P=-0.006） in T2DM group, and serum ZAG levelin HDL-C ≥ 1.04 group were higher than that of HDL- C〈1.04 group by hierarchical analysis with the cut-off value of HDL-C=1.04 mmol/L[（38.01 ±12.62） vs. （30.75 ± 9.00） mg/L,P= 0.011];Whereas the fasting serum ZAG level was positively correlated with TC in control group（r=0.292,P=0.O06）,the serum ZAG levelin the TC ≥ 5.18 group was higher than that of TC〈5.18 group by hierarchical analysis with the cut-off value of TC=5.18 mmol/L[（63.36 ± 12.03） vs. （56.97 ± 13.09） mg/L,P=0.022]. Conclusion： The adipoeyte factor ZAG may be correlated with the process of lipid metabolism disorder in T2DM,serum ZAG may play a beneficial role in promoting homeostasis of lipid metabolism.