六君子汤加减联合化疗治疗不可切除大肠癌肝转移的临床观察

Clinical observation of six Jun Zi decoction combined with chemotherapy in the treatment of non resection of colorectal cancer with liver metastasis

目的:观察六君子汤加减联合化疗治疗不可切除大肠癌肝转移患者的临床疗效。方法:选取我院2012年5月至2015年5月接诊的50例不可切除大肠癌肝转移患者进行研究,根据患者入院ID号尾号进行随机分组,将其均分为对照组和观察组。对照组采取单纯化疗治疗,观察组在对照组的基础上采取六君子汤加减治疗。对两组患者的临床疗效、治疗前后的生活质量评分、肝功能指标、肿瘤指标以及不良反应进行比较分析。结果:观察组患者治疗的总有效率(92.00%)明显高于对照组(68.00%),两组比较差异有统计学意义(P<0.05)。治疗前,两组患者的生活质量评分比较差异无统计学意义(P>0.05)。治疗后,观察组的生活质量评分(65.44±5.61分)明显高于对照组(58.31±5.28分),两组比较差异有统计学意义(P<0.05)。治疗前后,两组患者的谷丙转氨酶(ALT)、谷草转氨酶(AST)、γ-谷氨酰转肽酶(γ-GT)、总胆红素(TBIL)指标比较差异均不明显,无统计学意义(P>0.05)。治疗前,两组患者的肿瘤指标比较差异不明显,无统计学意义(P>0.05)。治疗后,观察组的癌胚抗原(CEA)水平(156.35±48.41μg/L)明显低于对照组(221.55±59.61μg/L),差异有统计学意义(P<0.05),两组糖链抗原19-9(CA19-9)、甲胎蛋白(AFP)比较差异不明显,无统计学意义(P>0.05)。观察组患者的不良反应发生率明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论:六君子汤加减联合化疗治疗不可切除大肠癌肝转移,能够提高临床疗效,改善患者生活质量,且具有安全性,值得广泛推广应用。

Objective：To observe the clinical effect of six gentleman soup plus subtraction combined with chemotherapy in the treatment of non resection of colorectal cancer with liver metastases.Methods：50 cases of non resectable liver metastases from colorectal cancer were studied in our hospital from May 2012 to May 2015.According to the number of the patients’ entrance number ID,the patients were randomly divided into the control group and the observation group.The control group was treated with chemotherapy alone, and the observation group was treated with Six Gentlemen soup on the basis of the control group.The clinical efficacy of the two groups, the quality of life before and after treatment, liver function index, tumor index and adverse reaction were compared and analyzed.Results：The total effective rate of treatment in the observation group（92%） was significantly higher than that of the control group（68%）, and the difference between the two groups was statistically significant（P〈0.05）.Before treatment, there was no significant difference in the quality of life score between the two groups（P〉0.05）.After treatment, the quality of life score of the observation group（65.44±5.61 points） was significantly higher than that of the control group（58.31±5.28 points）, and the difference between the two groups was statistically significant（P〈0.05）.Before and after treatment, two groups of patients with alanine aminotransferase（ALT） and aspartate aminotransferase（AST）, gamma glutamyltransferase（gamma-GT）, total bilirubin（TBIL） the differences are not obvious, no statistical significance（P 〉 0.05）.After treatment, the observation group of carcinoembryonic antigen（CEA） level（156.35±48.41 g/L） was significantly lower than the control group（221.55±59.61 u g/L）, there was statistically significant difference between the two groups（P〈0.05）, carbohydrate antigen 19-9（CA19-9）, and alpha fetoprotein（AFP） are no obvious difference, not statistically meaning（P 〉0.05）.The incidence of adverse reactions in the observation group was significantly lower than that in the control group, and there was a significant difference between the two groups（P〈0.05）.Conclusions Six Gentlemen Decoction Combined with chemotherapy in the treatment of liver metastasis of non resectable colorectal cancer can improve the clinical efficacy and improve the quality of life of patients. It is safe and worthy of wide application.