常压直接离子化-离子迁移谱法快速筛查玩具中4种初级芳香胺

Rapid Screening of Four Primary Aromatic Amines in Toys by Ambient Ionization and Ion Mobility Spectrometry

采用常压直接离子化结合离子迁移谱技术,研究并建立了蜡笔、纹身贴纸、液体玩具、手指画颜料、橡皮泥等多种玩具样品中2-萘胺、4-氯-2-甲基苯胺、4-氨基联苯和联苯胺4种初级芳香胺的现场快速筛查方法。样品无需经过繁琐的前处理过程,不同玩具样品采用纸喷雾、纳升萃取喷雾等常压直接离子化方法,将取样、萃取、电离等步骤集成为一步实现,并在12ms内完成离子迁移谱的仪器分析检测,4种初级芳香胺的方法检出限在0.5~2mg/kg之间。对于经离子迁移谱快速筛检出的疑似阳性样品,同时还建立了高效液相色谱-串联质谱确证方法。本方法快速便捷,适用于玩具质量安全现场快速筛查检测。

A rapid,on-site screening method has been developed for the identification of four primary aromatic amines in various toy samples（crayon,temporary tattoo sticker,liquid toys,finger paint and modeling clay）using ambient ionization coupled with ion mobility spectrometry（IMS）.Without any time-consuming sample preparation,sampling,extraction and ionization were integrated into a one-step protocol based on paper spray or extraction nano-electrospray.The IMS instrumental analysis time for a single run was less than 12 ms with the limits of detection（LODs）ranging from 0.5 to 2 mg/kg for the primary aromatic amines in toys.The suspicious positive samples were subjected to further verification by high performance liquid chromatography-tandem mass spectrometry（HPLC-MS/MS）.The method is fast,convenient,and can be used to ensure the quality and safety of toy products.