烟碱型乙酰胆碱受体在血管性认知功能障碍中的作用

Role of nicotinic acetylcholine receptors in vascular cognitive impairment

烟碱型乙酰胆碱受体（nAChRs）在认知功能中起重要作用。血管性认知功能障碍（VCI）的发生严重影响患者的健康及生活质量。通过对VCI的早期诊断和及时有效的干预，有可能延迟甚至阻止痴呆的发生。随着nAChRs神经受体显像剂的不断研发，更适合人体显像的受体显像剂不断出现；PET／CT、PET／MR等分子影像技术的发展和应用，推动了VCI的相关研究发展，为VCI的早期诊断和治疗提供了强有力的支持。该文综述了VCI的发病机制、nAChRs与VCI的关系、nAChRs受体显像的研究进展以及VCI的治疗。

Nicotinic acetylcholine receptors （nAChRs） play an important role in cognitive function. Vascular cognitive impairment （VCI） seriously affects the health and quality of life. Early diagnosis and timely effective intervention of VCI may delay or even prevent the occurrence of dementia. The development of nAChRs agents and molecular imaging, such as PET/CT or PET/MR, may promote research on the early diagnosis and treatment of VCI. This review summarizes the pathogenesis of VCI, the relationship between nAChRs and VCI, the progress on nAChRs receptor imaging, and the treatment of VCI.