摘要
Asymmetric Iron or Cobalt Catalysis Based on Ligand Design Although precious metal catalysts have been used for asymmetric transformations to achieve high enantioselectivities, the high cost to remove trace amounts of precious metals for pharmaceutical utiliW and potential depletion of precious metals make the development o f green, sustainable base-metal catalysts for efficient asymmetric transformations highly desirable. Furthermore, the distinct electronic structures and unique redox ability of base-metals provide numerous opportunities for exploring new reactivity311 Recently, we have developed a number of chiral ligands containing chiral oxazoline or imidazoline for iron or cobalt catalysis. The iron and cobalt complexes of these ligands showed high efficiencies and enantioselectivities for the catalytic asymmetric hydrofunctionalization[2] of alkenes, [3] alkynes,[4] and ketones[5] Additionally, asymmetric photocatalysis is also involved in my research group.[6]
Asymmetric Iron or Cobalt Catalysis Based on Ligand Design Although precious metal catalysts have been used for asymmetric transformations to achieve high enantioselectivities, the high cost to remove trace amounts of precious metals for pharmaceutical utiliW and potential depletion of precious metals make the development o f green, sustainable base-metal catalysts for efficient asymmetric transformations highly desirable. Furthermore, the distinct electronic structures and unique redox ability of base-metals provide numerous opportunities for exploring new reactivity311 Recently, we have developed a number of chiral ligands containing chiral oxazoline or imidazoline for iron or cobalt catalysis. The iron and cobalt complexes of these ligands showed high efficiencies and enantioselectivities for the catalytic asymmetric hydrofunctionalization[2] of alkenes, [3] alkynes,[4] and ketones[5] Additionally, asymmetric photocatalysis is also involved in my research group.[6]
