补肾强筋胶囊联合钙尔奇D对乳腺癌芳香化酶抑制剂相关骨丢失患者骨代谢的影响

Clinical observastion of Bushen-Qiangjin capsule and calcium D on aromatase inhibitors-induced osteopenia in breast cancer patients

目的 观察补肾强筋胶囊联合钙尔奇D对乳腺癌芳香化酶抑制剂治疗相关骨丢失（aromatase inhibitors-associated bone loss,AIBL）患者骨代谢的影响.方法 将符合入选标准的65例AIBL患者按就诊顺序随机分为对照组32例和治疗组33例.对照组给予钙尔奇D,治疗组在对照组的基础上加用补肾强筋胶囊.2组均治疗3个月.观察2组骨密度（bone mineral density,BMD）及血清骨碱性磷酸酶（bone alkaline phosphate,BALP）、骨钙素（osteocalcin,BGP）、抗酒石酸酸性磷酸酶（tartrate-resistant acid phosphatase,TrACP）的变化.结果 治疗后,治疗组BMD[（-1.16±0.28）g/cm3比（-1.71±0.40）g/cm3,t=8.062]高于对照组（P〈0.01）;血清BALP[（308.76±10.99）U/L比（280.00±7.44）U/L,t=12.003]、BGP[（42.21±3.04）ng/ml比（34.38±2.06）ng/ml,t=13.900]水平高于对照组（P〈0.01）,TrACP[（60.12±4.58）U/L比（67.25±4.06）U/L,t=1.653]水平低于对照组（P〈0.05）.结论 补肾强筋胶囊联合钙尔奇D可升高乳腺癌AIBL患者的BMD,改善骨代谢.

Objective To observe the clinical effect of the Bushen-Qiangjin capsule and calcium D in the treatment of aromatase inhibitors-associated bone loss （AIBL） in breast cancer patients. Methods A total of 65 patients were randomized into a treatment group and a control group, 32 in the control group taking calcium D, and 33 in the treatment group taking calcium D and Bushen-Qiangjin capsule. After a 3-month treatment, the bone mineral density T （BMD）, bone-specific alkaline phosphatase （BALP）, bone gla protein （BGP） and tartrate resistant acid phosphatase （TrACP） of two groups were evaluated. Results The BMD increased significantly after treatment in both groups （P〈0.05）, and the therapeutic efficacy of the treatment group was better than of the control group （P〈0.05）. After treatment, the level of BALP （308.76 ± 10.99 U/L vs. 280.00 ± 7.44 U/L, t=8.170） and the BGP （42.21 ± 3.04 ng/ml vs. 34.38 ± 2.06 ng/ml, t=6.818） of the treatment group were significantly higher than those of the control group （P〈0.01）. The level of TrACP decreased significantly after treatment in both groups （P〈0.05）, and the TrACP （60.12 ± 4.58 U/L vs. 67.25±4.06 U/L, t=1.653） of treatment group was significantly lower than that of the control group （P〈0.05）. Conclusions The Bushen-Qiangjin capsule can produce a content efficacy in treating AIBL in breast cancer patients, improving the BMD and bone metabolism.