含熟地黄成方制剂证治用药规律挖掘研究

Data mining analysis of prescription rules of traditional Chinese patent medicine containing prepared rehmannia root

目的 分析《中华人民共和国卫生部药品标准·中药成方制剂》（以下简称《中药成方制剂》）含熟地黄成方制剂的证治用药规律.方法 检索《中药成方制剂》中含有熟地黄的成方制剂,利用＂中医传承辅助平台（V2.5）＂软件构建数据库,采用频数统计、关联规则等数据挖掘方法,对含熟地黄成方制剂主治证候、药物组合进行分析,并对高频药对配伍规律和核心证候的组方规律进行深度分析.结果 含熟地黄成方制剂共467首,常用药物组合28个（支持度为30%）,其中高频药对（支持度为40%）＂熟地黄-当归＂和＂熟地黄-黄芪＂配伍来源均为《太平惠民和剂局方》十全大补汤.主治证候共81种,频次较高（频次≥10）的有16种,其中高频主治证候气血两虚证（137次）和肾阳虚证（63次）核心药物组合分别为十全大补汤和《景岳全书》右归丸加减.结论 含熟地黄成方制剂中熟地黄主要与养血、益气和补阳药配伍,主治证候主要为气血两虚证、肝肾亏虚证、肾阳虚证等,多以古代名方为基础方.本研究可为熟地黄的临床应用和新药研发提供参考.

Objective To analyze the treatment and medication rules of formulae containing prepared rehmannia root in Pharmaceutical Standard of Ministry of Public Health of the People＇s Republic of China-Traditional Chinese Patent Medicine （referred to as Traditional Chinese Patent Medicine）. Methods Through Traditional Chinese Medicine Inheritance Support Platform （V2.5）, prescriptions containing prepared rehmannia root in traditional Chinese patent medicine were selected and collected to build the database. Frequency counts,association rules and other data mining methods were used to analyze the frequency of indication syndromes and medicine combination of prescription containing prepared rehmannia root, and the compatibility rule of high frequency drug pairs and the rescription rule of core syndromes were analyzed. Results There were a total of 467 prescriptions containing pepared rehmannia root, involving 28 combinations of commonly used Chinese herbals （support degree 30%）. The compatibility source of high-frequency drug pairs of prepared rehmannia root and Angelicae Sinensis, prepared rehmannia root and Astragalus embranaceus were both of Shiquan-Dabu decoction in Taiping Huimin Heji Ju Fang （support degree 40%）. There were a total of 81 indication syndromes, and among them, there were 16 kinds of high-frequency indication syndromes （the frequency greater than or equal to 10）. The core drug combination of high-frequency indication syndromes of ＂deficiency of both qi and blood＂ （137 times） and ＂deficiency of kidney yang＂ （63 times） were the subtract of Shiquan-Dabu decoction and Yougui pill in Jingyue Quanshu respectively. Conclusions Prepared rehmannia root is mainly compatible with herbs of nourishing blood, supplementing qi and invigorating yang in the traditional Chinese patent medicine containing prepared rehmannia root. The traditional Chinese patent medicine containing prepared rehmannia root were based mainly on classical prescriptions. This study can provide reference for clinical application and new drug development of pepared rehmannia root.