脑梗通汤联合舒血宁注射液治疗脑梗死患者临床效果观察及对患者IL-6、IL-10、TNF-α、MMP-9水平影响

Clinical efficacy of Naogengtong decoction combined with Shuxuening injection in the treatment of patients with cerebral infarction and its effects on levels of IL-6,IL-10,TNF-α and MMP-9

目的:分析使用脑梗通汤结合舒血宁注射液对脑梗死病人实施治疗的临床效果和对病人IL-6、IL-10、TNF-α、MMP-9水平的影响。方法:以南昌大学第一附属医院收治的脑梗死病人176例作为本次研究主体,病人均为2014年2月~2017年2月来院接受治疗,根据病人的入院顺序分成对照组与观察组,每组病人88例。所选取的病人全部接受常规治疗,对照组通过单一使用舒血宁注射液实施治疗;观察组在对照组病人治疗的基础上加用脑梗通汤;所有病人的治疗疗程都是4周。比较两组治疗前后Barther指数,傅格梅尔氏评分(FMMS),改良阿什沃思评分(Ashwoeth),分析研究观察组与对照组病人治疗前以及治疗后IL-6、TNF-α以及MMP-9评分。结果:观察组的临床治疗效果明显优于对照组,观察组BI和FMMS评分明显高于对照组;治疗后观察组改良Ashworth和CSS评分明显低于对照组;观察组治疗后的IL-6、IL-10、TNF-α以及MMP-9水平均明显低于对照组。结论:使用脑梗通汤结合舒血宁注射液对脑梗死病人实施治疗的临床效果显著,能够有效改善病人IL-6、IL-10、TNF-α、MMP-9水平,可以推广。

Objective： To analyze the clinical efficacy of Naogengtong decoction combined with Shuxuening injection in the treatment of patients with cerebral infarction and its effects on levels of IL-6,IL-10,TNF-α and MMP-9. Methods： 176 cases of cerebral infarction in the first affiliated hospital of Nanchang University from February 2014 to February 2017 were devided into two groups according to the order of admission,each with 88 cases. Patients were all treated with routine treatment,in addition,patients in the control group were treated with Shuxuening injection,and those in the observation group were treated with Naogengtong decoction combined with Shuxuening injection. All patients were treated for 4 weeks. The Barther Index,the Foggel’s score（ FMMS）,the modified Ashworth score（ Ashwoeth）,IL-6,TNF-α,and MMP-9 scores before and after the treatment in two groups were compared. Results： The clinical efficacy in the observation group was significantly better than that in the control group（ P 〈 0. 05）. BI score and FMMS score in the observation group were higher than those in the control group（ P 〈 0. 05）. After the treatment,the ashworth score and CSS score in the observation group were lower than those in the control group（ P 〈 0. 05）. Levels of IL-6,IL-10,TNF-α and MMP-9 in the observation group were lower than those in the control group（ P 〈 0.05）. Conclusion： The clinical efficacy of Naogengtong decoction combined with Shuxuening injection in the treatment of cerebral infarction is significant,which can effectively improve levels of IL-6,IL-10,TNF-α and MMP-9 in patients.