养阴舒肝胶囊对多囊卵巢综合征伴不孕患者卵巢血流动力学和妊娠结局的影响

Efficacy of Yangyinshugan capsule on ovarian hemodynamics and pregnancy outcomes in patients with polycystic ovarian syndrome complicated with infertility

目的:探讨养阴舒肝胶囊对多囊卵巢综合征伴不孕患者卵巢血流动力学和妊娠结局的影响。方法:随机数字表法将2015年5月~2016年9月我院收治的100例多囊卵巢综合征伴不孕患者均分为对照组和观察组各50例,对照组患者从月经第五天开始口服枸橼酸氯米芬胶囊,50mg/次/天,观察组另给予养阴疏肝胶囊口服治疗,月经第五天开始,4粒/次,3次/天,两组均持续治疗3个月经周期,观察治疗前后两组卵巢血流动力学[搏动指数(PI)、阻力指数(RI)]、血清激素[促卵泡激素(FSH)、促黄体激素(LH)、雌二醇(E2)]、月经失调疗效、妊娠结局及药物安全性。结果:治疗前两组卵巢PI、RI、FSH、LH、E2相比较无明显差异;治疗后两组卵巢PI、FSH、E2较治疗前明显升高,RI、LH明显降低,且观察组的各项指标变化幅度较对照组明显;治疗后观察组月经失调总有效率76.00%、妊娠率68.00%,明显高于对照组50.00%、40.00%,两组药物不良反应发生率相比较无显著差异。结论:养阴舒肝胶囊对多囊卵巢综合征伴不孕患者的临床疗效明确,通过有效调节卵巢血流动力学、血清激素水平和月经周期,从而提高妊娠率,并有较高安全性。

Objective： To investigate the efficacy of Yangyinshugan capsule on ovarian hemodynamics and pregnancy outcomes in patients with polycystic ovarian syndrome complicated with infertility. Methods： 100 patients with polycystic ovarian syndrome complicated with infertility treated in our hospital from May 2015 to September 2016 were divided into the control group and the observation group with 50 patients in each group. Patients in the control group were treated with oral administration of Clomifene Citrate Capsules from the fifth day of the menstrual cycle,50 mg/time/day,while patients in the observation group were additionally treated with oral administration of Yangyinshugan capsule from the fifth day of the menstrual cycle,4 capsules/time,3 times/day,and all in two groups were treated for 3 menstrual cycles. Ovarian hemodynamics（ pulsatility index（ PI）,resistance index（ RI））,serum hormones（ follicle stimulating hormone（ FSH）,luteinizing hormone（ LH）,estradiol（ E2））,curative efficacy on menstrual disorders,pregnancy outcomes and drug safety in two groups were observed before and after the treatment. Results： There were no significant differences in PI,RI,FSH,LH and E2 between the two groups before the treatment（ P 〉 0. 05）. After the treatment,ovarian PI,FSH and E2 significantly increased while RI and LH significantly decreased in two groups,and changes in the observation group were more obvious than those in the control group（ P 〈 0. 05）. After the treatment,the total effective rate of treatment for menstrual disorders and pregnancy rate in the observation group（ 76. 00% and 68. 00%） were significantly higher than those in the control group（ 50. 00% and 40. 00%）（ P 〈 0. 05）,but there was no significant difference between two groups in the incidence of adverse drug reactions（ P 〉 0. 05）. Conclusion： Yangyinshugan capsule is effective in the treatment of polycystic ovarian syndrome with infertility. It can improve the pregnancy rate through effective regulation of ovarian hemodynamics,serum hormone levels and the menstrual. It is safe.