乳腺癌中HMGB1蛋白表达及其与Fascin-1的相关性

Expression of HMGB1 protein in breast cancer patients and its correlation with Fascin-1

目的探讨乳腺癌中高迁移率族蛋白B1（HMGB1）蛋白表达及其与Fascin-1蛋白表达的相关性。 方法采用免疫组织化学EnVision法检测98例乳腺癌组织中HMGB1和Fascin-1蛋白的表达及45例正常乳腺组织中HMGB1蛋白的表达情况。结果HMGB1蛋白在乳腺癌组织中阳性率为60.2%（59/98），较正常乳腺组织的15.6%（7/45）显著增强（P〈0.01）。Fascin-1蛋白在乳腺癌组织中阳性率为36.7%（36/98）。HMGB1蛋白阳性乳腺癌患者的Fascin-1蛋白表达率（45.8%，27/59）较HMGB1蛋白阴性患者（23.1%，9/39）显著增强（P〈0.05）。 结论乳腺癌中HMGB1高表达，其可能通过下游信号通路正性调控Fascin-1表达。

ObjectiveTo investigate the expression of high-mobility group box 1 （HMGB1） protein in breast cancer patients and its correlation with Fascin-1 protein expression.MethodsThe immunohistochemical technique, EnVision method, was used to evaluate the expression of HMGB1 and Fascin-1 in 98 patients with breast cancer, and HMGB1 protein was also detected in 45 cases of normal breast tissue.ResultsHMGB1 protein expression rates was significantly higher in breast cancer patients （60.2%, 59/98） than that in normal breast tissue （15.6%, 7/45）, P〈0.01. Fascin-1 protein expression rate in breast cancer was （36.7%, 36/98）. Fascin-1 expression rates was significantly higher in HMGB1 positive breast cancer cases （45.8%, 27/59） than that in HMGB1 negative cases （23.1%, 9/39）, P〈0.05.ConclusionsHMGB1 has high expression in patients with breast cancer, it can positively regulate Fascin-1 expression through the downstream signaling pathways.