微通道反应器中制备2-溴噻吩的工艺研究

Study on preparation of 2-bromothiophene in a micro-channel reactor

利用微通道反应器设计了连续合成2-溴噻吩的新工艺,并分别从反应温度、停留时间、物料配比等方面进行了研究,确定了最佳的工艺合成条件:在n(噻吩)∶n(HBr)∶n(H_2O_2)=1∶1.25∶1.375、反应温度为25℃、停留时间为30 s时,噻吩的转化率为84.3%,选择性为79.9%。与传统间歇釜式工艺相比,微通道反应器工艺的反应时间明显缩短,操作过程安全简便,产品转化率高、选择性好。

The new technology for continuous synthesis of 2-bromothiophene is designed by using microchannel reactor.The influences of reaction temperature,residence time and molar ratios among raw materials on the reaction are observed. The optimum process conditions are as follows： the conversion of thiophene and the selectivity of 2-bromothiophene can reach 84. 3% and 79. 9%,respectively when n（ thiophene） ∶ n（ HBr） ∶ n（ H2 O2） = 1 ∶1. 25 ∶1. 375,reaction temperature is 25℃ and residence time is 30 s. Compared with the traditional batch pot process,the microchannel reactor exhibits advantages of shorter reaction time,simpler and safer operation process,higher conversion rate and better selectivity.