摘要
多晶型研究是制药领域的一个研究热点,而多晶型体系的分子组装规律及其控制手段是最为关键的研究内容。介绍了多晶型的分子组装规律,即成核理论(包括经典成核理论以及新兴的二步成核理论),以及多晶型的调控方法,并重点介绍目前新型的调控手段(如离子液体、模板剂以及微通道技术等)。此外,结合药物晶型转化的实际案例,说明晶型转化技术在药物产品质量调控中的重要作用。
The study on pharmaceutical polymorphs is a hot topic in the field of drug. Meanwhile, the molecular assembly rules and the controlling methods of pharmaceutical polymorphs are the key contents in the research of polymorphs. In this paper, the nucleation theories, including the classical nucleation theory and two-step nucleation theory, as well as the methods about how to control pharmaceutical poly-morph are introduced. In particular, some new strategies for polymorph regulation are highlighted, such as ionic liquid, template agent and microchannel technology. In addition, two practical examples are used to illustrate the important role of phase transformation in improving the quality of pharmaceutical products.
作者
赵绍磊
王灵宇
吴送姑
Zhao Shaolei;Wang Lingyu;Wu Songgu(School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;National Engineering Research Center of Industrial Crystallization Technology, Tianjin University, Tianjin 300072, China)
出处
《化学工业与工程》
CAS
CSCD
2018年第3期12-21,共10页
Chemical Industry and Engineering
基金
国家自然科学基金创新研究群体项目(21621004)
国家科技重大专项(2017ZX09101001)
关键词
药物多晶型
成核理论
晶型控制
晶型转化
pharmaceutical polymorph
nucleation theory
polymorph regulation
phase transformation
