液滴-微流体环境下L-谷氨酸的多晶型现象

The Polymorphy of L-Glutamic Acid under Drop-Microfluidic System

利用液滴-微流体法研究了温度、液滴大小及溶剂组成对L-谷氨酸晶型的影响,并利用显微镜和PXRD进行了表征。研究结果表明,相同过饱和度下,温度越高越有利于亚稳态晶型的生成;反之,有利于稳态晶型的生成。相同过饱和度和温度下,液滴大小对晶型没有影响。溶剂中乙醇含量的增加有利于亚稳态晶型的生成。

The drop-microfluidic method was used to investigate the effect of temperature, droplet size and solvents composition on L-glutamie acid polymorphism. Microscope and powder X-ray diffraction （PXRD） were used to analyze the forms of crystals. The results show that the higher temperature favors the nucleation of metastable crystal form, while lower temperature favors the nucleation of stable crystal form under the same degree of supersaturation. When the degree of supersaturation and the crystallization temperature are same, droplet size has no effect on L-glutamic acid polymorphs. The higher the mole fraction of ethanol in ethanol aqueous solution is, the higher the percentage of metastable crystals is.