前列地尔联合贝那普利治疗糖尿病肾病蛋白尿的临床疗效

Clinical effect of alprostadil combined with benazepril in the treatment of diabetic nephropathy with proteinuria

目的探讨前列地尔联合贝那普利治疗糖尿病肾病蛋白尿的临床疗效。方法选取宜宾市第三人民医院2015年10月—2016年2月收治的糖尿病肾病蛋白尿患者98例,随机将患者分为对照组与观察组,各49例。对照组患者予以前列地尔治疗,观察组在对照组基础上予以贝那普利治疗。比较两组患者症状消失时间、住院时间、血压改善时间及临床疗效。结果观察组症状消失时间、住院时间、血压改善时间短于对照组,总有效率高于对照组(P<0.05)。结论前列地尔联合贝那普利治疗糖尿病肾病蛋白尿的临床疗效确切,可有效改善患者肾功能,缩短治疗时间。

Objective To analyze the efficacy of alprostadil combined with benazepril in the treatment of diabetic nephropathy with proteinuria.Methods A total of 98 cases of diabetic nephropathy with proteinuria patients were selected from October 2015 to February 2016 in the Third People＇s Hospital of Yibin,which were randomly divided into control group and observation group,49 cases in each group.The control group was treated with alprostadil,observation group was treated with benazepril based on control group.The symptoms disappeared time,hospitalization time,blood pressure improvement time and clinical effect were compared between the two groups.Results The observation group of symptoms disappeared time,hospitalization time,blood pressure improvement time were shorter than control group,total effective rate was higher than control group（P〈0.05）.Conclusion Alprostadil combined with benazepril have an obviously clinical effect in the treatment of diabetic nephropathy with proteinuria,it can effectively improve the renal function of patients,shorten treatment time.