依达拉奉注射液治疗急性脑梗死合并失语的临床效果观察

The clinical effect observation of edaravone injection in treatment of acute cerebral infarction with aphasia

目的观察依达拉奉注射液治疗急性脑梗死合并失语的疗效。方法将80例有失语的急性脑梗死患者随机分为治疗组和对照组各40例。治疗组给予依达拉奉注射液、血塞通和低分子右旋糖酐治疗;对照组除不使用依达拉奉以外,余治疗同治疗组。对比2组临床疗效。对比2组欧洲脑卒中量表(ESS)评分。采用Bathel Index(BI)指数评定日常生活活动能力,使用语言波士顿分级评定患者语言改善程度。结果治疗15 d和3个月时,治疗组总有效率均高于对照组,差异均有统计学意义(P<0.05)。2组治疗3个月的疗效均高于治疗15 d,差异均有统计学意义(P<0.05)。治疗前2组ESS评分比较差异无统计学意义(P>0.05)。2组治疗15 d和3个月时候的ESS评分均高于治疗前,且治疗组高于对照组,差异均有统计学意义(P<0.05)。治疗前2组BI和波士顿失语评分比较差异无统计学意义(P>0.05)。治疗后2组BI和波士顿失语评分均升高,且治疗组高于对照组,差异均有统计学意义(P<0.05)。结论依达拉奉注射液治疗急性脑梗死合并失语患者能有效改善患者的神经功能缺损情况,值得临床推广。

Objective To observe the clinical effect of edaravone injection in treatment of acute cerebral infarction with aphasia. Methods 80 cases patients with acute cerebral infarction combined with aphasia were randomly divided into treatment group and control group, each of 40 cases. Treatment group was treated by edaravone injection, bloodstonelow molecular dextran. Control group was treated by bloodstone low molecular dextran. After treatment, compared the clinical effect, ESS score, Bl,boston aphasia score of 2 groups. Results 15 days and 3 months after treatment,the total effective rate of the treatment group was higher than that of the control group, and the difference was statistically significant（ P 〈 0.05 ）. The total effective rate 3 months after treatment of 2 groups were higher than 15days after treatment, the difference was statistically significant （ P 〈 0.05 ）. The ESS score before treatment of 2 groups was no statistic significantly （ P 〉 0.05 ）. The ESS score 15 days and 3 months of 2 groups were higher than that before treatment, and the ESS score of treatment was higher than that of control group, the difference was statistic significantly（ P 〈0.05）. The BI and boston aphasia score of 2 group before treatment was no statistic significantly（P 〉 0.05 ）o The BI and boston aphasia score of 2 group after treatment were higher than that before treatment, and the treatment group was higher than that of control group, the difference was statistic significantly （ P 〈 0.05 ）. Conclusion Edaravone injection in the treatment of patients with acute cerebral infarction complicated by aphasia can effectively improve the neurological deficit in patients, and is worthy of clinical application.