舒芬太尼联合丙泊酚麻醉用于腹腔镜胆囊切除术患者的效果观察

The observation of anesthetic effect of sufentanil combined with propofol on patients with laparoscopic cholecystectomy

目的观察舒芬太尼联合丙泊酚麻醉用于腹腔镜胆囊切除术患者的效果。方法将106例腹腔镜胆囊切除术患者随机分为观察组和对照组,每组53例,观察组采用舒芬太尼联合丙泊酚麻醉,对照组采用瑞芬太尼联合丙泊酚麻醉,比较2组患者术后恢复情况、苏醒期镇静—躁动评分、术后拔管1 h疼痛程度及不良反应发生率。结果观察组自主呼吸恢复时间、睁眼时间、拔管时间及定向力恢复时间均明显长于对照组(P<0.01);观察组苏醒期镇静—躁动评分及术后拔管1 h视觉模拟评分均显著低于对照组(P<0.01);观察组不良反应发生率为11.32%明显低于对照组的35.85%,差异有统计学意义(P<0.01)。结论舒芬太尼联合丙泊酚麻醉可有效减轻腹腔镜胆囊切除术患者的苏醒期躁动及术后疼痛程度,且药物不良反应较少,值得临床推广应用。

Objective To observe the anesthetic effect of sufentanil combined with propofol on patients with laparoscopic cholecystectomy. Methods 106 cases of patients with laparoscopic cholecystectomy were randomly divided into observation group and control group,53 cases in each group. The observation group patients were anaesthetized with sufentanil and propofol,the control group patients were anaesthetized with remifentanil and propofol,the postoperative recovery,sedation-agitation scale,pain degree of 1 hour after extubation and rate of adverse reaction were compared between the two groups. Results The spontaneous breathing recovery time,eye opening time,extubation time and directional force recovery time of observation group patients were longer than those in control group（ P 〈0. 01）. The score of sedation-agitation scale in the awakening period and score of visual analogue scale of 1 hour after extubation in the observation group patients were lower than those of control group（ P〈 0. 01）. The rate of adverse reaction in observation group（ 11. 32%） was lower than that of control group（ 35. 85%）,the difference was statistically significant（ P 〈0. 01）. Conclusion The sufentanil combined with propofol anesthesia can effectually reduce the emergence agitation and postoperative pain of patients with laparoscopic cholecystectomy,and has fewer adverse reactions,it is worthy of clinical application.