瑞舒伐他汀与辛伐他汀治疗老年冠心病的疗效及对患者血脂水平影响的比较

Comparison of rosuvastatin and simvastatin in the treatment of elderly patients with coronary heart disease and its effect on blood lipid level

目的对比观察瑞舒伐他汀与辛伐他汀治疗老年冠心病的效果及其对患者血脂水平的影响。方法选取2015年3月-2017年3月医院收治的老年冠心病患者120例,按治疗方法差异将其分为观察组和对照组,每组患者60例。观察组在常规治疗基础上加用瑞舒伐他汀治疗;对照组加用辛伐他汀治疗。治疗4周后比较其临床疗效、血脂水平变化情况及安全性。结果观察组的总有效率为95.00%,高于对照组的76.67%,差异有统计学意义(χ2=10.805,P<0.05)。治疗4周后,2组各血脂指标较治疗前均显著改善(P<0.05),观察组TC、TG、LDL-C水平改善情况优于对照组(P<0.05)。2组患者治疗期间均无严重不良反应发生。结论瑞舒伐他汀治疗老年冠心病疗效确切,降脂效果好,安全性高,具有临床推广价值。

Objective To compare the effect of rosuvastatin and simvastatin in the treatment of elderly patients with coronary heart disease and its effect on blood lipid level. Methods 120 elderly patients with coronary heart disease admitted in the hospital from March 2015 to March 2017 were selected. According to the difference of treatment,120 patients were divided into observation group and control group,60 cases in each group. The observation group was treated with rosuvastatin on the basis of conventional treatment,while the control group was treated with simvastatin. After 4 weeks＇ treatment,the clinical efficacy,blood lipid level and safety between the 2 groups were compared. Results The total effective rate of the observation group was 95. 00%,which was higher than that of the control group（ 76. 67%）,and the difference was statistically significant（ χ2= 10. 805,P〈 0. 05）. After 4 weeks of treatment,the indexes of blood lipid in the two groups were significantly improved（ P〈 0. 05）. The improvement of the level of TC,TG and LDL-C in the observation group were better than that of the control group（ P〈 0. 05）. No serious adverse reactions occurred in the two groups during treatment. Conclusion Rosuvastatin in the treatment of elderly coronary heart disease is effective,with good lipid-lowering effect and high safety,and has the value of clinical promotion.