心脏外科术后成纤维细胞生长因子21变化与血糖相关性研究

Relationship between fibroblast growth factor 21 and blood glucose after cardiac surgical operation

目的探讨心脏外科手术后成纤维细胞生长因子21(FGF21)变化与血糖的关系。方法纳入无糖尿病的冠状动脉粥样硬化性心脏病患者86例,根据冠状动脉旁路移植术后患者血糖是否升高,将患者分为术后血糖正常组46例和术后血糖升高组40例,收集术前基线资料,测量术前、术后血浆FGF21水平,二元回归分析FGF21变化与血糖的关系。结果所有患者术后FGF21水平较术前显著升高[(7.49±0.53)μg/L vs(3.04±0.26)μg/L,P<0.01]。术后血糖正常组FGF21水平升高较术后血糖升高组更显著[(5.84±0.72)μg/L vs(2.84±0.46)μg/L,P<0.01]。循环FGF21水平变化与术后血糖升高相关(OR=10.67,95%CI:2.34~48.63,P<0.01)。结论冠状动脉旁路移植术术后血糖变化与FGF21水平显著相关,这对心脏外科术后血糖管理有重要意义。

Objective To study the relationship between fibroblast growth factor 21（FGF21）and blood glucose（BG）after cardiac surgical operation.Methods Eighty-six coronary atherosclerotic heart disease patients without DM were divided into postoperative normal BG group（n=46）and postoperative elevated BG group（n=40）.Their preoperative baseline data were recorded,their plasma FGF21 level was measured before and after operation.The relationship between FGF21 and BG was analyzed by dual regression analysis.Results The serum FGF21 level was signifycantly higher in two groups after operation than before operation（7.49±0.53μg/L vs 3.04±0.26μg/L,P〈0.01）and in postoperative normal BG group than in postoperative elevated BG group（5.84±0.72μg/Lvs 2.84±0.46μg/L,P〈0.01）.The circulating FGF21 level was related with the postoperative elevated BG level（OR=10.67,95%CI：2.34-48.63,P〈0.01）.Conclusion BG is closely related with FGF21 after coronary bypass,which is of great importance for the management of BG after cardiac surgical operation.