梅毒血清固定患者外周血中IL-17,IL-10表达及意义

Expressions and significance of IL-17, IL-10 in peripheral blood of patients with syphilis sera fixation

目的检测梅毒血清固定患者外周血中白细胞介素-17(IL-17)和白细胞介素-10(IL-10)的表达,并探讨其意义。方法分别选取梅毒血清固定患者、初诊梅毒患者、梅毒治疗后非梅毒螺旋体抗原转阴者和健康人各30例,分别记为A组、B组、C组和D组,分别采用酶联免疫吸附试验对各组血清IL-17和IL-10进行检测,对比组间差异。结果四组血清IL-17水平对比差异均无统计学意义(P>0.05),且每两组间血清IL-17水平对比差异也均无统计学意义(P>0.05);四组血清IL-10水平对比差异有统计学意义(P<0.05),且D组血清IL-10水平最高,B组其次,C组稍低,A组最低。结论在梅毒血清固定患者中外周血IL-17水平无明显变化,IL-10水平异常降低,可将其作为梅毒感染及临床疗效的辅助判断指标。

Objective To detect the expressions of interleukin -17 （1L-17） and interleukin -10 （IL-10） in peripheral blood of patients with syphilis sera fixation and to explore its significance. Methods Every 30 cases of syphilis sero immobilization, newly diagnosed syphilis, syphilis treated with non trepo- nema pallidum antigen negative and healthy persons were enrolled in the study, who were recorded as A group, B group, C group and D group respectively. The serum IL-17 and IL-10 levels were detected by enzyme-linked immunosorbent assay, and the differences were compared among the groups. Results There was no significant difference in serum IL-17 levels among the four groups （P〉 0.05）, and there were no significant differences in serum IL-17 levels between each two groups （P 〉 0.05）.The differences of sentrn IL-10 levels in the four groups were statistically significant （P 〈 0.05）, and the levels of serum IL-10 in the D group was the highest, the next in the B groups, of which the C groupwas slightly lower, and the level in the A group was the lowest. Conclusion In syphilis sero immobilized patients, the level of IL-17 in peripheral blood did not change significantly, and the level of IL-10 decreased. It could be used as an assistant index for syphilis infection and clinical efficacy.