亚临床甲状腺功能减退对妊娠合并症的影响

Influence of Subclinical Hypothyroidism on Pregnancy Complications

目的探讨妊娠合并亚临床甲状腺功能减退对妊娠期糖尿病、妊娠期高血压及子痫前期发病率的影响。方法选取2017年1月-2017年12月在某院建档并分娩的产妇共2970人。剔除孕前既有甲状腺功能疾病、糖尿病及高血压的产妇剩余2881人。其中妊娠合并亚临床甲状腺功能减退组453人,甲状腺功能正常即对照组2428人。亚甲减组根据左旋甲状腺素治疗后效果分为治疗达标组395人和未达标组58人。分别计算并比较达标组、未达标组及对照组的妊娠期糖尿病、妊娠期高血压及子痫前期的发病率。计数资料间比较采用X^2检验,统计学分析应用SPSS 19.0软件。结果未达标组妊娠期糖尿病、妊娠期高血压及子痫前期的发病率显著高于达标组和对照组,差异有统计学意义,P<0.05。达标组以上三种疾病的发病率高于对照组,但差异无统计学意义,P>0.05。结论妊娠合并亚临床甲状腺功能减退患者更易发生妊娠期糖尿病、妊娠期高血压及子痫前期,而左旋甲状腺素有助于减少亚甲减患者以上三种疾病的发生。

Objective To evaluate the influence of Subclinical hypothyroidism onthe morbidity of gestational diabetes mellitus,pregnancy hypertension and preeclampsia.Methods There were 2970 delivery in a hospital form January 1,2017 to December 31,2017.When exclude the cases of thyroid disease,diabetes mellitus and hypertension before pregnancy,there were 2881 cases.2428 cases of normal pregnancy as the control group and 453 cases of pregnancy with subclinical hypothyroidism as observation group.The observation group was divided into standard group（395 cases） and non-standard group（58 cases） based on the left-handed thyroid hormone（L-T4）treatment effect.Calculate and compare the morbidity of gestational diabetes mellitus,pregnancy hypertension and preeclampsia in standard group,non-standard group and control group.Enumeration data processed by X2 test,and statistical analysis were done with SPSS 19.0 software.Results The morbidities of gestational diabetes mellitus,pregnancy hypertension and preeclampsia in non-standard group were obviously higher than standard group and control group（P〈0.05）.The morbidities of these three diseases in standard group were higher than control group（P〉0.05）.Conclusion Patients with subclinical hypothyroidism are more easily to have gestational diabetes mellitus,pregnancy hypertension and preeclampsia.L-T4 treatment could be helpful to reduce the morbidity of these three diseases.