卡前列素氨丁三醇注射液联合宫腔填纱治疗前置胎盘剖宫产产后出血的疗效

Effect of romethamine injection combined with uterine filling in the treatment of postpartum hemorrhage of preplacentalcesarean section

目的观察卡前列素氨丁三醇注射液联合宫腔填纱治疗前置胎盘剖宫产产后出血的疗效。方法选取2014年5月至2017年3月建德市妇幼保健院妇产科收治的前置胎盘剖宫产产后出血患者100例为研究对象，采用随机数字表法将患者分成观察组和对照组，每组50例，观察组采用卡前列素氨丁三醇注射液联合宫腔填纱的治疗方法，对照组采用缩宫素联合宫腔填纱的治疗方法，比较两组临床疗效。结果观察组在分娩中的出血量与对照组差异无统计学意义（t＝1.335，P〉0.05），观察组产后2 h和24 h后的出血量均明显低于对照组[（657.58±63.21）mL比（875.23±65.42）mL、（712.52±64.32）mL比（958.12±74.66）mL]，两组差异均有统计学意义（t＝8.265、11.356，均P〈0.05）；对照组治疗前后心率、血压和血氧饱和度与观察组差异均无统计学意义（t＝3.255、2.365、4.153、1.225、3.365、2.658、4.365、1.654，均P〉0.05）。结论卡前列素氨丁三醇注射液联合宫腔填纱治疗前置胎盘剖宫产产后出血疗效显著，值得临床上推广应用。

ObjectiveTo investigate the effect of romethamine injection combined with uterine filling in the treatment of postpartum hemorrhage of preplacental cesarean section.MethodsFrom May 2014 to March 2017, 100 cases of placenta previa cesarean section postpartum hemorrhage in Jiande Maternal and Child Health Care Hospital Obstetrics and Gynecology were selected as the research objects, and they were randomly divided into observation group and control group according to the digital table, with 50 cases in each group.The observation group received romethamine injection combined with uterine filling treatment, the control group received oxytocin combined with uterine cavity filling treatment.The clinical curative effect of the two groups was compared.ResultsThe blood loss during delivery between the two groups had no statistically significant difference （t=1.335, P〉0.05）. Postpartum 2h and 24h, the blood loss of the observation group were significantly lower than those of the control group[（657.58±63.21）mL vs.（875.23±65.42）mL, （712.52±64.32）mLvs.（958.12±74.66）mL], the differences between the two groups were statistically significant （t=8.265, 11.356, all P〈0.05）. Before and after treatment, the heart rate, blood pressure and blood oxygen saturation between the two groups had no statistically significant differences（t=3.255, 2.365, 3.255, 2.365, t=3.365, 2.658, 4.365, 1.654, all P〉0.05）.ConclusionRomethamine injection combined with uterine filling in the treatment of postpartum hemorrhage of preplacental cesarean section has significant effect, it is worthy of application.