2014～2016年武汉地区31家医院质子泵抑制药的使用情况分析

Analysis on the Application of Proton Pump Inhibitors in 31 Hospitals in Wuhan Area from 2014 to 2016

目的:分析2014~2016年武汉地区31家医院质子泵抑制药(PPIs)的使用情况,为临床上该类药物的合理应用提供参考依据。方法:对2014~2016年武汉地区31家医院PPIs的使用品种、用药剂型、销售金额、用药频度(DDDs)、限定日费用(DDC)、药品销售金额排序(B)/DDDs排序(A)以及进口用药构成比等进行统计,分析PPIs的应用现状。结果:2014~2016年武汉地区31家医院PPIs的销售金额与DDDs呈逐年递增趋势。用药剂型以口服为主,但注射用药构成比仍然较高。3年中销售金额与DDDs增速最快的分别是口服泮托拉唑与注射用兰索拉唑;注射用奥美拉唑的销售金额与DDDs却呈现大幅下降的趋势。口服泮托拉唑的DDDs排序连续3年居第1位,且其B/A值远大于1。大多数PPIs的同步性较好且DDC逐年减少。除埃索美拉唑外,PPIs的用药均以国产为主。结论:2014~2016年武汉地区31家医院PPIs的使用基本趋于合理,但仍存在不合理用药的可能性,需进一步加强监控,促进临床合理用药。

Objective： To investigate the application characteristics of proton pump inhibitors（ PPIs） in 31 hospitals in Wuhan area from 2014 to 2016 to provide reference for the clinical rational use. Methods： The utilization of PPIs in 31 hospitals in Wuhan area from 2014 to 2016 was statistically analyzed by drug types and dosage form in terms of consumption sum,DDDs,DDC,and consumption ranking（ B）/DDDs ranking（ A）,etc. Results： The consumption sum and DDDs of PPIs were rising year by year. As for the dosage form,the most commonly used one was oral preparation,however,the percent of injection kept high level. Among the different PPIs,oral poptolazole and lansorazole for injection were with the fastest increase in consumption sum and DDDs,while the consumption sum and DDDs of omeprazole for injection significantly decreased. The DDDs of oral poptolazole ranked first in the continuous three years with the B/A value much higher than 1. 0. The synchronicity was good for most of PPIs and the DDC was decreasing year by year. Moreover,PPIs were dominated by domestic products except for esomeprazole. Conclusion： The use of PPIs in 31 hospitals in Wuhan area from 2014 to 2016 was basically reasonable. However,some potential irrational application in clinic may still exist. Therefore,the application monitoring for PPIs should be further strengthened to promote rational drug use in clinics.