基于T细胞免疫的维生素D对银屑病治疗机制的研究进展

Advances in the study of the mechanism of vitamin D treatment of psoriasis from the perspective of T cell immunity

银屑病发病机制复杂包括遗传、免疫、精神状况等因素,而各种Th细胞在银屑病发病中具有重要作用。维生素D及其衍生物对银屑病具有良好防治作用,且维生素D对银屑病的治疗作用可能与T细胞有较大联系。文章主要从Th1/Th2、Th9、Th17、Treg等角度阐述银屑病发病机制的研究进展以及维生素D对银屑病预防治疗机制的进展,期望为后续相关研究提供思路与切入点。

The pathogenesis of psoriasis is complex,including genetic,immune and many other factors,and Th cell play an important role in this process. Vitamin D excerts excellent therapeutic effect on psoriasis,and the therapeutic effect may be related to T cells. In this passage,we look into the recent advances in the pathogenesis of psoriasis from the perspectives of Th1/Th2,Th9,Th17,Treg and the advances in treatment of psoriasis with vitamin D,for providing some ideas and entry points for future research.