抗生素与α-受体阻滞剂治疗慢性盆腔疼痛的临床疗效对比

Comparison of clinical effects of antibiotics and α receptor antagonist in treatment of chronic pelvic pain

目的探讨抗生素与α-受体阻滞剂对盆腔炎引起的慢性盆腔疼痛(CPP)的治疗效果及其复发情况,为临床治疗CPP提供参考意见。方法选取2015年1月-2016年5月在该院接受治疗的慢性盆腔炎引起的慢性盆腔疼痛女性患者180例,按照随机数字表法分为观察组和对照组,每组各90例。对照组采用青霉素治疗,观察组采用盐酸特拉唑嗪治疗,观察并比较两组患者治疗前后的视觉模拟评分法(VAS),治疗效果及总有效率,不良反应发生情况。治疗后3个月进行随访,观察并比较两组患者CPP复发情况。结果两组患者治疗前VAS评分比较差异无统计学意义(P>0.05);治疗后,两组患者VAS评分均降低,且观察组低于对照组(P<0.01)。观察组患者治疗总有效率稍高于对照组患者,差异无统计学意义(P>0.05)。观察组患者整体治疗效果优于对照组,差异有统计学意义(P<0.05)。治疗后3个月进行随访,观察组CPP的复发率明显低于对照组,差异有统计学意义(χ2=7.850,P=0.005)。结果α-受体阻滞剂可以明显缓解盆腔炎引起的CPP,整体治疗效果较好,复发率低。

Objective To explore the curative effects of antibiotics and α receptor antagonist in treatment of chronic pelvic pain（ CPP）caused by pelvic inflammatory diseases and the recurrence,provide a reference for clinical treatment of CPP. Methods A total of 180 patients with CPP caused by pelvic inflammatory diseases treated in Jinzhou People＇s Hospital from January 2015 to May 2016 were selected and divided into observation group and control group according to random number table,90 patients in each group. The patients in control group were treated with penicillin. The patients in observation group were treated with terazosin hydrochloride. VAS scores before and after treatment,curative effects,total effective rates,and adverse reactions in the two groups were observed and compared. All the patients were followed up for three months,the recurrence rates of CPP in the two groups were observed and compared. Results There was no statistically significant difference in VAS score before treatment between the two groups（ P〈0.05）. After treatment,VAS scores in the two groups decreased significantly,and VAS score in observation group was statistically significantly lower than that in control group（ P〈0.01）. The total effective rate in observation group was slightly higher than that in control group,but the difference was not statistically significant（ P〈0.05）. The overall curative effect in observation group was statistically significantly better than that in control group（ P〈0.05）. At three months after treatment,the recurrence rate of CPP in observation group was statistically significantly lower than that in control group（ χ~2=7. 850,P = 0. 005）. Conclusion α receptor antagonist can significantly alleviate CPP caused by pelvic inflammatory diseases,the overall curative effect is good,and the recurrence rate is low.