基因调控在胆道闭锁发病中的作用

Effect of gene regulation in pathogenesis of biliary atresia

胆道闭锁（BA）是小儿外科常见的严重肝脏疾病，是新生儿胆汁淤积的常见病因，以肝内、外胆道系统的进行性炎症和纤维化闭锁为主要特征。其发病机制复杂，可能与基因突变、遗传易感性、病毒感染、免疫反应、炎症、血管因素、母体因素等相关，但具体机制不详。随着对BA研究的不断深入及研究方法的不断改进，BA基因水平的改变及调控越来越引起大家的广泛关注。

Biliary atresia （BA） is a common neonatal liver disease characterized by inflammation and fibrosis of the extrahepatic biliary ducts, leading to cholestasis and biliary cirrhosis. It is also a severe liver disease in infants. The pathogenesis of BA is associated with multiple genes and gene polymorphism, virus infections, epigenetic, immune abnormalities, and so on. With the development of genetic technology, it provides a new method to determine the susceptibility genes in BA. Now, more and more doctors pay attention to the change and regulation of genes in BA.