硒结合蛋白1在肝癌中的表达及其临床意义

Expression and significance of selenium binding protein 1 in liver cancer

目的探讨硒结合蛋白1(selenium binding protein 1,SBP1)在肝癌组织中的表达及其可能的临床意义。方法采用组织芯片技术以及免疫组化SP法检测118例肝癌组织和10例非癌肝组织中SBP1的表达,并分析其与肝癌临床病理特征的关系。结果 SBP1在118例肝癌组织有60例表达阳性,阳性表达率为50.85%,而在10例非癌肝组织中有9例表达为阳性,阳性表达率为90%。SBP1的表达与肝癌的肿瘤大小、浸润深度和TNM分期相关(P<0.05),而与年龄、性别、分化程度、淋巴结转移无关(P>0.05)。结论 SBP1在肝癌组织中的低表达与肿瘤大小、浸润深度和TNM分期有关,可能作为一种新的肿瘤分期和判断预后的标志物,有望成为肝癌治疗新的靶点。

Objective To investigate the expression and significance of selenium binding protein 1（SBP1）in liver cancer.Methods Tissue microarray and immunohistochemistry SP method were used to detect the expression of SBP1 in 118 cases of liver cancer tissue and 10 non-cancerous liver tissue.Results Positive expression of SBP1 was 50.85%（60/118）in the liver cancer,but 90%（9/10）of non-cancerous liver tissue.The positive expression of SBP1 was correlated to the size of tumor,depth of invasion and TNM stage of liver cancer（P〈0.05）,not correlated to the age,gender,tumor differentiation and lymphatic metastases（P〈0.05）,respectively.Conclusion Low expression of SBP1 is associated with the TNM stage and tumor size of liver cancer.It may be a new marker for prognosis of patients with liver cancer.