摘要
目的分析卡马西平治疗前庭阵发症的有效性和安全性。方法选取2013年6月至2017年6月我院神经内科收治的前庭阵发症患者82例,根据用药不同将其分为卡马西平组(CBZ)31例、卡马西平+倍他司汀组(CBZ+BMT)26例和奥卡西平+倍他司汀组(OXC+BMT)25例。用药3个月后比较3组患者临床疗效、发作频率、眩晕程度及不良反应。
结果CBZ组治愈14例、好转13例,治疗有效率为87.1%(27/31);CBZ+BMT组治愈18例、好转7例,治疗有效率为96.2%(25/26);OXC+BMT组治愈15例、好转8例,治疗有效率为92.0%(23/25);3组治疗有效率差异无统计学意义(χ^2=0.783,P=0.129)。用药治疗3个月后,3组患者中CBZ+BMT组发作频率和眩晕程度最低,CBZ组发作频率和眩晕程度最高(均P〈0.05)。CBZ组共发生不良反应16例,占51.6%;CBZ+BMT组发生不良反应8例,占30.8%;OXC+BMT组发生不良反应4例,占16.0%。结论卡马西平与奥卡西平治疗前庭阵发症疗效相似,联合倍他司汀疗效显著,且安全可靠。
ObjectiveTo evaluate the efficacy and safety of Carbamazepin(CBZ)compared with Oxcarbazepine(OXC)therapy for vestibular paroxysmia.
MethodsEighty-two patients with vestibular paroxysmia were admitted during June 2013 and June 2017 in this study.According to the agents administered, all patients were divided into the CBZ group(n=31), CBZ+ Betahistine(BMT)group(n=26)and OXC+ BMT group(n=25). The clinical efficacy, frequency, vertigo and adverse reactions of three groups were compared after 3 months follow-up.ResultsIn CBZ group, 14 cases were cured, 13 were improved, and the effective rate was 87.1%.In CBZ+ BMT group, 18 cases were cured, 7 were recovered, and the effective rate was 96.2%.In OXC+ BMT group, 15 cases were cured, 8 cases were recovered, and the effective rate was 92.0%.There was no significantly difference in effective rate among the three groups(χ^2=0.783, P=0.129). Meanwhile, the CBZ+ BMT group had the lowest frequency of vestibular paroxysmia and vertigo degree, while the CBZ group was the highest; the difference in the frequency and vertigo degree between groups was statistically significant(P〈0.05). Furthermore, the incidences of side-effects were 51.6%(n=16), 30.8%(n=8)and 16.0%(n=4)in the CBZ group, CBZ+ BMT group and OXC+ BMT group, respectively.ConclusionsThe effect of Carbamazepine and Oxcarbazepine for vestibular paroxysmia is similar, and is safely and significantly improved when combined with Betahistine.
作者
张超
向莉
邓倩
刘春岭
段志毅
李慧
Zhang Chao;Xiang Li;Deng Qian;Liu Chunling;Duan Zhiyi;Li Hui(Department of Neurology, North District, Second Affiliated Hospital of Zhengzhou University, Zhengzhou , 450000 Chin;Department of Neurology ,People' s Hospital of Henan ,Zhengzhou, 450000,Chin;Department of Neurology ,Affiliated Hospital of Nan yang Medical College, Nan yang 473000 , China)
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2018年第6期687-689,共3页
Chinese Journal of Geriatrics
关键词
卡马西平
倍他司汀
前庭疾病
Carbamazepine
Betahistine
Vestibular diseases