环氧二十碳三烯酸与代谢综合征的研究进展

Epoxyeicosatrienoic acids and metabolic syndrome..a literature review

代谢综合征是一种以代谢紊乱为主要特点的复杂症候群，包括中心性肥胖、血压升高、血糖异常和血脂异常等特征性症状。随着生活方式及人口老龄化的，老年人已成为代谢综合征的高危人群，并显著增加心脑血管事件的发生风险。环氧二十碳三烯酸近年来被发现在高血压、心肌缺血及动脉粥样硬化等方面有着重要的作用，其可上调血红素氧合酶1，二者相互作用，从而达到降低炎性反应和氧化应激，并改善内皮功能和胰岛素抵抗等作用。本综述旨为代谢综合征的诊治提供新的诊疗思路及干预靶点。

Metabolic syndrome including four components of central obesity, hypertension, dyslipidemia, and hyperglycemia, is a complex syndrome.Along with the improvement of life conditions and population aging, elderly people become a high risk population for metabolic syndrome, in whom the risks for cardio-and cerebro-vascular events are obviously increased.For the past few years, epoxyeicosatrienoic acids（EETs）are found to improve patient′s condition of hypertension, myocardial ischemia, and atherosclerosis.Moreover, EETs can up-regulate HO-1 expression.EETs and HO-1 interaction attenuates inflammatory response and oxidative stress, regulates vascular endothelial function, enhances insulin sensitivity, and improves insulin resistance.This review takes aim at providing a new approach to diagnosis of, and a new target for therapeutic intervention of metabolic syndrome.