重氮化合物参与的连续流动反应

Continuous Flow Reaction of Diazo Compounds

重氮化合物是一种用途广泛的有机砌块,能够作为1,3-偶极子、亲核试剂以及卡宾前体参与到各种有机分子的构建之中.但重氮化合物潜在的毒性、不稳定性以及爆炸风险限制了它的应用潜力.连续流动技术在这一领域的应用能够有效保证反应的安全性,并为重氮化合物的大批量应用提供了可能.按照重氮化合物的种类分类,系统地归纳了近年来连续流动技术在重氮化合物参与的各种转化中的应用.

Diazo compounds are versatile building blocks in organic synthesis. They are served as 1,3-dipoles, nucleophiles and carbene precursors in the construction of various organic molecules. However, the utility of diazo compounds is significantly limited by toxicity, instability and explosive potential. The application of continuous flow technology in this field could ensure the safety of these reactions. It also provides the possibility to utilize diazo compounds in a large scale. Categorized by the types of diazo compounds, the application of continuous flow technology in transformations of diazo compounds is systematically reviewed in this paper.