摘要
报道了一种以简单、易得的氯化铵为胺源,合成伯酰胺的酰胺化方法.以N-甲基吡咯烷酮(NMP)为溶剂和缚酸剂,在加热的条件下各种脂肪酰氯和芳香酰氯都能与氯化铵快速地反应,以良好到优秀的收率得到相应的伯酰胺,该反应为伯酰胺的合成提供了一种快速、实用的方法.
A practical amidation reaction for the synthesis of primary amides is presented, in which the simple NH4C1 was identified as a practical and convenient amine source. A series of aromatic and aliphatic acid chlorides were successfully com- patible with this protocol, affording the corresponding amides in good to excellent yields, which provides a rapid and reliable approach to amides from simple starting materials. Introducing the appropriate N-methyl pyrrolidone （NMP） into the system as solvent and acid-binding reagent plays a key role to avoid the use of stoichiometric amounts of base.
作者
李哲健
高宝
黄汉民
L Zhejian;Gao Bao;Huang Hanmin(College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014;Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemistry, University of Science and Technology of China, Hefei 230026)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2018年第6期1431-1436,共6页
Chinese Journal of Organic Chemistry
基金
Project supported by the National Natural Science Foundation of China(Nos.21672199
21702197)
the CAS Interdisciplinary Innovation Team
the Fundamental Research Funds for the Central Universities
the Anhui Provincial Natural Science Foundation(No.1708085MB28)~~
关键词
铵盐
酰胺化
伯酰胺
酰氯
N-甲基吡咯烷酮
ammonium salts
amidation
primary amides
acid chlorides
N-methyl pyrrolidone
