三氯异氰尿酸作为氯源实现α-氰基酮和1,3-二羰基类化合物的氯化

Chlorination of α-Cyanoketones and 1,3-Dicarbonyl Compounds by Using Trichloroisocyanuric Acid as Chlorine Source

报道了以三氯异氰尿酸作为氯源,在室温条件下高效实现了α-氰基酮类化合物和1,3-二羰基类化合物氯化反应的研究.该反应过程条件温和,无需额外添加氧化剂或碱.

The a-chlorination of α-substituted-α-cyano ketone compounds and 1,3-dicabonyl compounds is described. Using 0.34 equiv, trichloroisocyanuric acid as chlorine source, the chlorination can efficiently access at room temperature in a mild condition without additional oxidant or base. The chloride products can be obtained in a higher yield.