摘要
N-乙烯基唑化合物因其优异的生物活性,是医药、农药等领域中重要的活性中间体.以唑类化合物为原料,2,3-二溴丙酸甲酯为Michael受体,近室温无金属催化合成了22种具有反式烯烃基团的N-乙烯基唑化合物,其中包括15种新化合物.研究表明,该反应条件温和,普适性好,能够高效合成立体选择性的N-乙烯基唑化合物.
A metal-free synthetic protocol for N-vinylazoles has been developed. Twenty-two structurally diversed N-vinylazoles including 15 new compounds are obtained with good to high yield at near room temperature, and all of products consist trans-alkene moieties with high stereoselectivity.
作者
李爽
向恒
姜瑞航
居佳
焦鹏冲
苑华磊
孙宏滨
蔡华强
Li Shuang;Xiang Heng;Jiang Ruihang;Ju Jia;Jiao Pengchong;Yuan Hualei;Sun Hongbin;Cai Huaqiang(Department of Chemistry, Northeastern University, Shenyang 110819;Institute of Chemical Materials, China Academy of Engineering Physics, Mianyang 621900;New Material Research Center in Siehuan, Chengdu 610000)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2018年第6期1493-1499,共7页
Chinese Journal of Organic Chemistry
基金
Project supported by the Sci-Tech Innovation Funds for Institute of Chemical Materials(No.KJCX-201502)~~