肠黏膜机械屏障与肠易激综合征的关系

The Relationship between Intestinal Mucosa Mechanical Barrier and Irritable Bowel Syndrome

肠易激综合征作为胃肠疾患的常见病,其发病机制与肠黏膜屏障、胃肠动力、内脏敏感性、脑-肠-菌轴等密切相关。其中肠黏膜机械屏障作为肠黏膜屏障最基础、最重要的屏障,近年来,对此开展的研究相对较多。肠黏膜机械屏障同肠黏膜化学、肠黏膜生物、肠黏膜免疫屏障构成肠黏膜屏障,共同抵御内毒素、病原菌等有害物质,维持肠道内环境稳态。肠黏膜机械屏障由肠黏膜上皮细胞、黏液层、紧密连接结构共同构成,任一环节异常,均会造成黏膜破坏,导致肠易激综合征。本文主要就肠黏膜机械屏障与肠易激综合征的关系做一综述,以期为临床实验提供思考方向与理论支持。

Irritable bowel syndrome is a common disease in gastrointestinal diseases, and its pathogenesis is closely related to intestinal mucosal barrier, gastrointestinal motility, visceral sensitivity, brain-gut-bacterial axis and so on. The intestinal mucosal mechanical barrier is the most important barrier for intestinal mucosa, and it has been studied comparatively in recent years.Intestinal mucosal mechanical barrier, Intestinal mucosal chemical barrier, intestinal mucosal biological barrier, intestinal mucosal immune barrier are consist of intestinal mucosal barrier, jointly resist bacterial endotoxin, pathogenic bacteria and other harmful substances, maintaining the homeostasis. Intestinal mucosal mechanical barrier is composed of intestinal mucosal epithelial cells,mucous layer and tight junction. Any abnormality in any link can cause the mucous membrane damage, leading to irritable bowel syndrome. In this paper, the relationship between intestinal mucosal mechanical barrier and irritable bowel syndrome is reviewed in order to provide the theoretical support for clinical trials.