可逆性脑后部白质病变综合征影像学特点分析

Analysis of imaging features of reversible posterior leukoencephalopathy syndrome

目的探讨可逆性脑后部白质病变综合征的影像学特点。方法回顾性分析11例可逆性脑后部白质病变综合征患者的影像学资料。结果患者中累及枕叶9例,顶叶8例,额叶8例,基底节6例,颞叶2例,胼胝体1例和小脑1例。CT平扫示枕叶、顶叶、额叶、基底节、颞叶、胼胝体和小脑等低密度。MRI平扫示T_1WI为低信号、T_2WI及Flair为高信号。DWI可呈等或稍高信号,ADC可呈等、稍高、高或低信号。结论可逆性脑后部白质病变综合征可累及部位主要局限于顶枕叶,但额叶、基底节、颞叶、胼胝体及小脑等部位亦可受累。Flair、DWI和ADC序列对病变最为敏感。

Objective To explore the radiological features of reversible posterior leukoencephalopathy syndrome（RPLS）. Methods The neuroimage data of 11 RPLS patients were retrospectively analyzed. Results The lesions involved occipital lobe in 9 patients,parietal lobes in 8 patients,frontal lobe in 8 patients,basal ganglia in 6 patients,temporal lobe in 2 patients,corpus callosum in 1 patient,and cerebellum in 1 patient. CT scan showed lowdensity in occipital lobe,parietal lobes,frontal lobe,basal ganglia,temporal lobe,corpus callosum and cerebellum.MRI scan showed low T1WI signal,and increase in T2WI signal. DWI showed isointense or slightly hyperintense,and ADC showed isointense,slightly hyperintense,hyperintense or hypointense signal. Conclusions The lesions in RPLS mainly cover parietal lobes and occipital lobe,however,the frontal lobe,basal ganglia,temporal lobe,corpus callosum and cerebellum can also be affected. The sequences of Flair,DWI and ADC are most sensitive to the lesions of RPLS.