纤维基组织工程支架结构对细胞行为的影响

Effects of Fibrous Scaffolds Structure on Cell Behavior

有效引导细胞的生长对于组织工程的发展至关重要,而目前研究表明细胞与支架的相互作用受到材料表面结构的影响,这为设计细胞诱导生长的新型支架提供理论依据。通过静电纺丝技术制备的纤维基支架可以模拟天然细胞外基质的纤维网络结构,对于细胞的生长和组织修复有促进作用,因此成为组织工程支架设计的研究热点。从纤维直径、空间排列、孔径等方面综述支架结构对细胞增殖、迁移、分化等行为的影响,并进一步讨论利用静电纺和静电纺复合技术制备不同纤维结构的常用方法,并展望纤维基支架的未来发展方向。

Effective strategies to guide cell growth are critical for the development of engineered tissues,and the surface morphology and properties of the biomaterials have appreciable impact on the biocompatibility and biological function, thus the regulation of cell behaviors can provide theoretical supports for developing biocompatible tissue engineering scaffolds. The fibrous scaffolds fabricated by electrospinning could mimic the network structure of the natural extracellular matrix（ ECM）,supporting cell attachment and guiding tissue formation,therefore fabricating micro-or nanofibers scaffolds are becoming of great interest in the area of biomaterials and tissue engineering. The effect of structural parameters of electrospun scaffolds on the cell behavior was reviewed in this paper, including fiber diameter, pore size, and fiber arrangement. The perspective of fibrous scaffolds and the current improved electrospinning methods for preparing different fibrous structures were also summarized.