双重超声造影在评价胃癌血管生成中的应用价值

Application values of double contrast enhanced ultrasonography in the diagnosis of micro vessel formation on gastric cancer

目的探讨双重超声造影技术在评价胃癌血管生成的应用价值。方法选取2015年8月至2017年10月在本院择期行手术治疗的胃癌患者52例,均先行口服胃窗超声造影,再行经静脉超声造影,于检查后3～5 d内行手术治疗。观察胃癌胃超声造影检查的图像特征,记录胃癌病变区与正常胃壁时间-强度曲线(TIC)参数,并分析其与胃癌组织微血管密度(MVD)、血管内皮生长因子(VEGF)表达的关系。结果胃癌病变组织与正常胃壁组织比较,基础强度(BI)、增强强度(EI)、峰值强度(PI)、灌注时间(WIT)差异均具有统计学意义(P <0. 05);相关性分析显示,胃癌组织的EI、PI均与MVD呈正相关,BI、WIT与MVD呈负相关(P<0.05);胃癌组织EI、PI与VEGF呈正相关,BI与VEGF呈负相关(P<0.05)。结论胃超声造影检查可准确评估胃癌组织的血流灌注特征,对评估胃癌的血管生成具有一定的应用价值。

Objective To discuss the application of double contrast enhanced ultrasonography in the diagnosis of micro vessel formation on gastric cancer. Methods 52 cases of patients with gastric cancer who scheduled for elective tumor resection on our hospital from August 2015 to October 2017 were enrolled in the study. Oral ultrasonic contrast agent, and intravenous contrast agent were used to assess the preoperative condition. The image feature of gastric ultrasound imaging was observed, and the time-intensity curve （TIC） parameters of gastric lesions and normal gastric were recorded, the relationship of gastric carcinoma TIC parameters and the expression of micro vessel density （MVD） , vascular endothelial growth factor （VEGF） expression were analyzed. Results Comparison of gastric lesions and normal gastric tissue, there were statistically significant difference on the basic strength （BI） , enhanced intensity （EI） , peak intensity （PI）, perfusion time （WIT） （P 〈0. 05 ） ; Correlation analysis showed that EI, PI were positively correlated with MVD, BI, WIT was negatively correlated with MVD （P 〈 0. 05 ） ; El, PI were positively correlated with VEGF, BI was negatively correlated with VEGF （ P 〈 0. 05 ）. Conclusions Gastric ultrasound imaging technology can accurately assess the blood perfusion characteristics of gastric carcinoma, with a certain value on the gastric cancer angiogenesis evaluation.